Nucleic acids are complex biological molecules that store and transmit genetic information in all living organisms. They are essential for the survival and reproduction of life on Earth. The two main ...

Guanine quadruplexes (G-quadruplexes or G4s) are unusual nucleic acid structures with distinct biological and chemical functions. They have occupied significant attention in the nucleic acid world ...

Nucleic acids such as DNA and RNA play a central role in gene therapies and vaccines. They store and transmit biological ...

Peptide nucleic acids (PNAs) represent a revolutionary class of synthetic nucleic acid analogues, in which the traditional sugar–phosphate backbone is replaced by a neutral N-(2-aminoethyl) glycine ...

DNA—the biological information-storage unit and the mechanism by which traits are passed on from generation to generation—is more than just an essential molecule of life. In the chemical sense, the ...

DNA and RNA are central to laboratory and clinical research, where quantifying their abundance is key to applications such as gene expression analysis, cell and gene therapy development, and ...

This schematic shows the secondary structure of two aptamers. The complex shapes formed by base pairing (black lines connecting G-C and A-T bases) allow aptamers to bind their targets with high ...

For the first time, scientists have developed artificial nucleotides, the building blocks of DNA, with several additional properties in the laboratory. The DNA carries the genetic information of all ...

DNA is the poster child for high-specificity binding. As long as their base sequences match, two complementary strands of DNA can navigate through a sea of biomolecules, find each other, and hold fast ...

A researcher is developing a patent-pending platform technology called LENN that mimics the dual-layer structure of viruses to deliver nucleic acid (NA)-based therapies to targeted cancer cells. A ...