Androgen receptor gene mutation, rearrangement, polymorphism
Sep 12, 2013 · Androgen receptor gene mutation, rearrangement, polymorphism Abstract: Genetic aberrations of the androgen receptor (AR) caused by mutations, rearrangements, and …
Androgen receptor expression predicts breast cancer survival: the role ...
The role of defects in the regulation of Androgen receptor gene expression were examined by mutation and methylation screening of the 5' end of the gene, reporter assays of the 5' and 3' end of the AR …
Androgen receptor mutations and androgen insensitivity
Dec 30, 2002 · The androgen receptor (AR) is a high affinity receptor protein encoded on the human X-chromosome that mediates the actions of androgens during development and in the adult. Defects in …
Real-world prevalence and outcomes of androgen receptor ligand …
Feb 18, 2025 · Background: Anti-hormonal therapies targeting the androgen receptor (AR) pathway are the standard of care treatment for patients with prostate cancer (PC). However, patients can develop …
Prevalence and Spectrum of - PubMed
Abstract Purpose: Metastatic castration-resistant prostate cancer (mCRPC) is typically treated with agents directly or indirectly targeting the androgen receptor (AR) pathway. However, such treatment …
Androgen receptor mutations modulate activation by 11 ... - PubMed
Background: Androgen receptor (AR) ligand-binding domain (LBD) mutations occur in ~20% of all castration-resistant prostate cancer (CRPC) patients. These mutations confer ligand promiscuity, but …
The Effect of F877L and T878A Mutations on Androgen Receptor …
Jul 5, 2016 · Abstract. Treatment-induced mutations in the ligand-binding domain of the androgen receptor (AR) are known to change antagonists into agonists. Recently, the F877L mutation has …
A novel nonsense mutation in androgen receptor confers resistance …
Keywords: prostate cancer, androgen receptor, androgen receptor mutation, CYP17 inhibitor, abiraterone INTRODUCTION Prostate cancer (PCa) is the second leading cause of cancer mortality …
Androgen receptor variants: RNA-based mechanisms and therapeutic ...
The androgen receptor (AR) transcription factor is a master regulator of normal glandular homeostasis in the prostate, as well as growth and survival of prostate cancer cells. Therefore, AR-targeted …
Structural and molecular insights into the mechanism of resistance to ...
Oct 1, 2022 · Androgen receptor (AR) is a key contributing element in the prostate cancer (PCa) instigation, progression and it is among the vastly discovered target for prostate cancer. Numerous …