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  1. Leptomeningeal Disease: What It Is, Symptoms & Prognosis

    Leptomeningeal disease (also known as LMD, leptomeningeal metastases, or LM) is cancer in your cerebrospinal fluid and in your leptomeninges, the membranes that surround your brain …

  2. Leptomeningeal Disease: Current Approaches and Future Directions

    Leptomeningeal disease (LMD), or spread of cancer cells into the pia and arachnoid membranes encasing the brain and spinal cord, is associated with high symptom burden and poor survival …

  3. Leptomeningeal Cancer Symptoms, Treatment and Prognosis

    Leptomeningeal disease (LMD), also known as leptomeningeal carcinomatosis, is a condition where cancer spreads to the brain, spinal fluid and leptomeninges, the thin layers of tissue …

  4. Leptomeningeal Metastasis - AIM at Melanoma Foundation

    Leptomeningeal metastasis—also called leptomeningeal carcinomatosis, leptomeningeal disease, or simply “LMD”—is the spread of cancer to a particular part of the brain called the …

  5. Leptomeningeal Disease | Neuro-Oncology Program | UPMC …

    Leptomeningeal Disease (LMD) happens when cancer cells invade the fluid and protective membranes surround the brain and spinal cord. Learn more from UPMC.

  6. Leptomeningeal Disease, CNS Metastasis | Moffitt

    Leptomeningeal disease (LMD) is a rare form of central nervous system (CNS) metastasis that occurs when cancerous cells spread to the leptomeninges—the delicate layers of tissue that …

  7. Surviving LMD: Michelle Never Settled for “No”

    Jun 12, 2025 · Leptomeningeal disease, or LMD, occurs when cancer from somewhere in the body spreads to the cerebrospinal fluid and leptomeninges that surround the brain and spinal …

  8. Clinical features and diagnosis of leptomeningeal disease ... - UpToDate

    Jul 14, 2025 · Leptomeningeal disease (LMD; also referred to as leptomeningeal metastases or carcinomatous meningitis) is a rare but frequently devastating complication of advanced …

  9. Leptomeningeal Disease Treatment | Mount Sinai - New York

    Leptomeningeal disease occurs when tumor cells gain access to cerebrospinal fluid pathways, learn more about treatment options at Mount Sinai.

  10. Leptomeningeal metastatic disease: new frontiers and future …

    Dec 9, 2024 · In this Review, a multidisciplinary group of experts describe the emerging evidence and areas of active investigation in LMD and provide directed recommendations for future …