p53 - Wikipedia
p53, also known as tumor protein p53, TP53, cellular tumor antigen p53 (UniProt name), or transformation-related protein 53 (TRP53) is a regulatory transcription factor protein that is often …
Tumor Suppressor p53: Biology, Signaling Pathways, and Therapeutic ...
This is a heavily studied pathway in cancer biology and oncology with a history that dates back to 1979 when p53 was discovered. The p53 pathway is a complex cellular stress response network with …
Targeting p53 pathways: mechanisms, structures and advances in …
Mar 1, 2023 · Here, we provide a systematic review of the diverse molecular mechanisms of the p53 signaling pathway and how TP53 mutations impact tumor progression. We also discuss key …
Phosphorylated p53: Function, Regulation, and Role in Cancer
Jun 29, 2025 · The p53 protein, often called “the guardian of the genome,” is a tumor suppressor that helps prevent cells from becoming cancerous. As a transcription factor, it can bind to DNA and …
TP53 gene: MedlinePlus Genetics
The TP53 gene provides instructions for making a protein called tumor protein p53 (or p53). This protein acts as a tumor suppressor, which means that it regulates cell division by keeping cells from growing …
P53 - an overview | ScienceDirect Topics
p53 is one of the most mutated tumor suppressors in human cancers and as such has been intensively studied for a long time. p53 is a major orchestrator of the cellular response to a broad array of stress …
TP53 - illustrated-glossary.nejm.org
Jan 23, 2026 · The p53 protein is a transcription factor that controls the expression of hundreds of target genes by binding and activating specific target genes that, once transcribed and translated, suppress …
Understanding the complexity of p53 in a new era of tumor suppression
May 9, 2024 · Here, we review the complexity of different layers of p53 regulation, and the recent advance of the p53 pathway in metabolism, ferroptosis, immunity, and others that contribute to tumor …
Primary information of p53 gene
p53, also known as TP53 or tumor protein (EC :2.7.1.37) is a gene that codes for a protein that regulates the cell cycle and hence functions as a tumor suppression. It is very important for cells in multicellular …
p53 Function and Dysfunction in Human Health and Diseases
The perturbation of p53 signaling pathways is required for the development of most cancers; however, it is now becoming clear that p53 has a much broader role in human health and diseases.